Deep vein thrombosis (DVT) is a serious vascular condition in which blood clots form in the deep veins of the legs or pelvis, restricting circulation and increasing the risk of life-threatening complications such as pulmonary embolism (PE). Catheter-directed thrombolysis (CDT) is a minimally invasive treatment that quickly dissolves blood clots, restores normal blood flow, and prevents long-term vein damage.
At Vascular Surgery Associates, our board-certified vascular specialists in Los Angeles and Santa Monica provide advanced catheter-directed thrombolysis to help patients safely and effectively treat DVT and reduce the risk of complications.
Understanding Deep Vein Thrombosis (DVT) and Its Risks
DVT occurs when a blood clot (thrombus) forms in a deep vein, typically in the legs. If left untreated, the clot can break loose and travel to the lungs, leading to a pulmonary embolism (PE), a life-threatening emergency.
Common Symptoms of DVT
- Swelling in one leg (most common)
- Pain or tenderness in the leg, especially when walking
- Skin warmth and redness over the affected vein
- Leg cramping, particularly in the calf
Many cases of DVT go undiagnosed because symptoms may be mild or absent, making early detection critical for preventing complications.
Risk Factors for DVT
Prolonged immobility
Long flights, car rides, or extended bed rest
Recent surgery or hospitalization
Increased risk of clotting due to inactivity
Cancer or cancer treatments
Some cancers increase clotting risk
Hormone therapy or birth control pills
Estrogen-based medications can contribute to clot formation
Smoking
Increases clotting risk and damages blood vessels
Family history of blood clots
Genetic factors can contribute to DVT
If you experience symptoms of DVT, seek immediate medical evaluation to prevent serious complications.
How Catheter-Directed Thrombolysis Works to Dissolve DVT Clots
Catheter-directed thrombolysis is a minimally invasive endovascular procedure designed to rapidly break down and remove blood clots before they cause permanent vein damage or lead to a pulmonary embolism.
Step-by-Step Overview of the Procedure
- A thin catheter is inserted into the affected vein through a small puncture, typically in the groin or behind the knee.
- A clot-dissolving medication (thrombolytic agent) is delivered directly to the blood clot.
- The catheter remains in place for several hours to overnight, allowing the medication to fully break down the clot.
- A specialized clot-removal device may be used to physically extract the clot if necessary.
- The catheter is removed, and blood flow is restored, reducing swelling and pain.
This technique is highly effective in preventing long-term complications, such as post-thrombotic syndrome (PTS), which can cause chronic leg pain, swelling, and venous ulcers.
Who is a Candidate for Catheter-Directed Thrombolysis?
Catheter-directed thrombolysis is recommended for patients with severe or extensive DVT who:
- Have a large blood clot causing significant swelling and pain
- Are at risk for pulmonary embolism (PE)
- Have clots in major veins, such as the iliac or femoral veins
- Have not responded to standard blood-thinning medications
- Are at risk for long-term venous complications like post-thrombotic syndrome (PTS)
Our vascular specialists at Vascular Surgery Associates evaluate each patient’s condition, medical history, and clot severity to determine if catheter-directed thrombolysis is the best treatment option.
Benefits of Catheter-Directed Thrombolysis for DVT
Catheter-directed thrombolysis offers numerous advantages over traditional blood clot treatments, making it an ideal choice for patients with severe DVT.
Minimally invasive
No large incisions, reducing recovery time
Fast-acting treatment
Breaks down blood clots within hours to days
Prevents complications
Reduces the risk of post-thrombotic syndrome (PTS)
Lower risk of pulmonary embolism (PE)
By dissolving large clots before they migrate
Improves long-term vein function
Prevents permanent vein damage and chronic swelling
Short hospital stay
Many patients are discharged within 24-48 hours
By choosing Vascular Surgery Associates, patients receive expert care from leading vascular specialists using the latest techniques in clot removal.
Frequently Asked Questions About Catheter-Directed Thrombolysis for DVT
No, patients receive local anesthesia and mild sedation, ensuring a comfortable experience during the procedure.
The procedure typically takes 1-3 hours, and patients may require an overnight hospital stay for monitoring.
Most patients experience significant symptom relief within 24-48 hours and can return to normal activities within a few days to a week.
Yes, patients typically continue taking anticoagulants (blood thinners) for several months to prevent new clots from forming.
Most insurance plans, including Medicare, cover thrombolysis for DVT if medically necessary. Our team assists with insurance verification and coverage details.

Dedicated to Excellence in Vascular Care Since 1963
Vascular Surgery Associates (VSA) has established itself as a cornerstone of vascular health in Southern California, combining decades of experience with cutting-edge treatment methods. Founded by visionary surgeons in 1963, our practice has grown from pioneering beginnings into one of the busiest and most respected vascular surgery groups in the Western United States.
Get Expert DVT Treatment in Los Angeles & Santa Monica – Schedule a Consultation Today
Deep vein thrombosis is a serious vascular condition, but catheter-directed thrombolysis offers a fast, effective solution to dissolve blood clots and restore healthy circulation. At Vascular Surgery Associates, our leading vascular specialists in Los Angeles and Santa Monica provide advanced, minimally invasive DVT treatments to help patients avoid complications and long-term vein damage.
Contact us today to schedule a consultation and explore your treatment options for deep vein thrombosis (DVT).